Research Technician II Opening

The Ethier lab seeks a Research Technician II to study stem cell delivery to the anterior eye as a potential treatment for glaucoma. Glaucoma is the second most common cause of blindness and is frequently associated with an elevated intraocular pressure. Using an established mouse model of glaucoma, we wish to deliver stem cells to a specific location in the eye by loading the cells with magnetic nanoparticles and “steering” them with an external magnet. The resulting changes in intraocular pressure, anterior segment morphology and aqueous outflow facility will be measured. The successful candidate will undertake these studies as part of a collegial and diverse team of research staff, students and post-docs. This position is funded from an NIH R01 grant.

KEY RESPONSIBILITIES: The specific job duties include the following:

• Assisting with delivery of stem cells to the trabecular meshwork in mice, including maintenance of mouse colonies, cell culture, and stem cell injection into the eye

• Monitoring changes in mice due to stem cells, including intraocular pressure, outflow facility, trabecular meshwork cell distribution and number, and immunohistochemistry.

• Compiling data and statistical analysis of compiled data

• Closely interacting with lab members participating in this project.

PREFERRED EDUCATION, SPECIALIZED KNOWLEDGE AND EXPERIENCE: Degrees required for this job: undergraduate degree in biomedical engineering, biology, or a closely related field by the time of hiring.

PREFERRED YEARS OF EXPERIENCE REQUIRED FOR THIS JOB: 0+ after undergraduate degree.

PREFERRED KNOWLEDGE AND SKILL QUALIFICATIONS: Experience working with mice (breeding, anesthesia), experience with cell culture, and good experimental skills are strongly desired. Previous familiarity with the eye would be a major plus. Proven ability to work as part of a diverse team and contribute to a positive lab culture; and to communicate effectively, both verbally and in writing.

SPECIALIZED SKILLS:

• Significant experience in: mouse breeding, mouse anesthesia, microscopy, cell culture

• Knowledge of: ocular physiology and anatomy

Interested applicants should send the following items, complied into a single pdf, to ross.ethier@bme.gatech.edu: (i) a cover letter outlining relevant experience; (ii) the names and contact details of 3 referees; (iii) a complete CV. The position is for full-time employment on the Georgia Tech campus, with a minimum commitment of 1 year.

Post-doctoral Fellow Opening

The Ethier lab seeks a Post-doctoral Fellow to study retinoscleral signaling in myopia. The pathogenesis of myopia is poorly understood but involves signaling from the retina to the sclera by one or more factors, likely including all-trans retinoic acid. We will mathematically model this signaling process, including transport across the choroid, and carry out tracer studies in post-mortem mouse eyes to obtain model validation datasets. The successful candidate will undertake these studies as part of a collegial and diverse team of research staff, students, and post-docs, working in collaboration with personnel from the laboratory of Dr. Machelle Pardue. This position is funded from a recent NIH R01 grant.

KEY RESPONSIBILITIES: The specific job duties include the following:

• Mathematical modeling of transport from the retina to the sclera, including consideration of carrier binding, choroidal vessel exclusion, and active transport across the retinal pigment epithelium

• Assisting with the design and execution of experiments in which the movement of fluorescent tracers is optically tracked across and between different layers of the ocular wall

• Preparing manuscripts and abstracts for scientific meetings.

• Mentoring of graduate and undergraduate students, as appropriate and in conjunction with the lab PI.

PREFERRED EDUCATION, SPECIALIZED KNOWLEDGE AND EXPERIENCE:

Degrees required for this job: PhD in engineering, biophysics, applied mathematics, or a closely related field.

PREFERRED YEARS OF EXPERIENCE REQUIRED FOR THIS JOB: 0+ after Ph.D.

PREFERRED KNOWLEDGE AND SKILL QUALIFICATIONS: Strong knowledge of biotransport, including both modeling and experimental aspects. Previous familiarity with the eye would be a major plus. Proven ability to work as part of a diverse team and contribute to a positive lab culture; to communicate effectively, both verbally and in writing; and to assist with preparation of grants.

SPECIALIZED SKILLS:

• Significant experience in: Mathematical modeling, microscopy, biotransport

• Knowledge of: ocular anatomy

Interested applicants should send the following items, complied into a single pdf, to ross.ethier@bme.gatech.edu: (i) a cover letter outlining relevant experience; (ii) the names and contact details of 3 referees; (iii) a complete CV.